Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2015 English Publisher:Elsevier BVJournal:Materials Today Communications, volume 4, pages 86-92 (issn: 2352-4928,

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Authors: Janet, Manono; Casey A, Dougherty; Kirsten, Jones; Joshua, DeMuth; Mark M Banaszak, Holl; Stassi, DiMaggio;

doi: 10.1016/j.mtcomm.2015.06.006

pmid: 26549978

pmc: PMC4631223

Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios

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Abstract

The synthesis, isolation, and characterization of generation 3 poly(amidoamine) (G3 PAMAM) dendrimer containing precise ratios of 5-carboxytetramethylrhodamine succinimidyl ester (TAMRA) dye (n = 1-3) per polymer particle are reported. Stochastic conjugation of TAMRA dye to the dendrimer was followed by separation into precise dye-polymer ratios using rp-HPLC. The isolated materials were characterized by rp-UPLC, MALDI-TOF-MS, and 1H NMR spectroscopy, UV-vis, and fluorescence spectroscopies.

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