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Trends in Molecular Medicine
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Trends in Molecular Medicine
Article . 2011 . Peer-reviewed
License: Elsevier TDM
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https://pubmed.ncbi.nlm.nih.go...
Article . 2015
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Trends in Molecular Medicine
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Sirtuin-1 regulation of mammalian metabolism

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2011 English Publisher:Elsevier BVJournal:Trends in Molecular Medicine, volume 17, pages 8-13 (issn: 1471-4914, Copyright policy )
Authors: Derek M. Erion; Gerald I. Shulman; Matthew P. Gillum;

doi: 10.1016/j.molmed.2010.09.005

pmid: 20971038

pmc: PMC3123438

Sirtuin-1 regulation of mammalian metabolism

Abstract

Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on data obtained in vivo, we review how SirT1 orchestrates the adaptive response to fasting by stimulating hepatic gluconeogenesis and fatty acid oxidation, increasing circulating adiponectin levels and limiting immune activation. Finally, we consider its viability as a therapeutic target for the treatment of type 2 diabetes.

Related Organizations
Keywords

Mammals, Diabetes Mellitus, Type 2, Sirtuin 1, Gluconeogenesis, Animals, Humans

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 97
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
97
Top 10%
Top 10%
Top 1%
bronze