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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Trends in Molecular Medicine
Article . 2003 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Trends in Molecular Medicine
Article . 2004
Data sources: Europe PubMed Central
Trends in Molecular Medicine
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Thrombin interaction with platelet membrane glycoprotein Ibα

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2003 English Publisher:Elsevier BVJournal:Trends in Molecular Medicine, volume 9, pages 461-464 (issn: 1471-4914, Copyright policy )
Authors: Marie-Christine Bouton; Martine Jandrot-Perrus; Frédéric Adam; Marie-Geneviève Huisse;

doi: 10.1016/j.molmed.2003.09.009

pmid: 14604821

Thrombin interaction with platelet membrane glycoprotein Ibα

Abstract

The interaction of thrombin with platelet glycoprotein Ibalpha (GPIb alpha) is required for optimal platelet activation. The crystal structures of platelet GPIb alpha bound to thrombin reported by Dumas et al. and Celikel et al. both reveal the simultaneous interaction of GPIb alpha with thrombin exosites I and II but differ markedly regarding how the two proteins interact. The possible consequences on thrombus formation of thrombin interacting with GPIb alpha are discussed in light of these new data.

Related Organizations
Keywords

Blood Platelets, Platelet Glycoprotein GPIb-IX Complex, Cell Membrane, Thrombin, Animals, Humans, Phosphorylation, Blood Coagulation

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 28
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
28
Average
Top 10%
Top 10%
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