The Notch and Sonic hedgehog signalling pathways in immunity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2004 English Publisher:Elsevier BVJournal:Molecular Immunology, volume 41, pages 715-725 (issn: 0161-5890,

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Authors: Robert A, Benson; Jacqueline A, Lowrey; Jonathan R, Lamb; Sarah E M, Howie;

doi: 10.1016/j.molimm.2004.04.017

pmid: 15220006

The Notch and Sonic hedgehog signalling pathways in immunity

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Abstract

There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.

Related Organizations

Medical Research Council
United Kingdom
Centre for Inflammation Research
United Kingdom
University of Edinburgh
United Kingdom

Keywords

CD4-Positive T-Lymphocytes, Receptors, Notch, Membrane Proteins, Cell Differentiation, Pneumonia, Immune System, Neoplasms, Trans-Activators, Animals, Humans, Hedgehog Proteins, Signal Transduction

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