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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Molecular Cell
Article . 2024 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article . 2024
Data sources: Europe PubMed Central
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Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2024 English Publisher:Elsevier BVJournal:Molecular Cell, volume 84, pages 1,635-1,636 (issn: 1097-2765, Copyright policy )
Authors: Ruey-Hwa, Chen;

doi: 10.1016/j.molcel.2024.04.003

pmid: 38701740

Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis

Abstract

In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.

Related Organizations
Keywords

Cell Nucleus, Ubiquitin-Protein Ligases, Proteolysis, Ubiquitination, Humans, Homeostasis, Animals, Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Nucleotidyltransferases

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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