Glutamate Dehydrogenase to the Rescue

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2018 English Publisher:Elsevier BVJournal:Molecular Cell, volume 69, pages 1-2 (issn: 1097-2765,

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Authors: Jonathan L, Coloff;

doi: 10.1016/j.molcel.2017.12.015

pmid: 29304329

Glutamate Dehydrogenase to the Rescue

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Abstract

Tumor cell metabolism can be altered to support specific pathological functions or to adapt to environmental stresses. In this issue of Molecular Cell, Jin et al. (2018) identify induction of glutamate dehydrogenase as a critical metabolic adaptation in matrix-detached cancer cells that is required for metastasis of LKB1-deficient lung tumors.

Related Organizations

Harvard University
United States

Keywords

DNA-Binding Proteins, Lung Neoplasms, Glutamate Dehydrogenase, Humans, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Protein Serine-Threonine Kinases, Anoikis, Signal Transduction

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