The RAS/MAPK Axis Gets Stressed Out

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2016 English Publisher:Elsevier BVJournal:Molecular Cell, volume 64, pages 854-855 (issn: 1097-2765,

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Authors: Scott A, Foster; Shiva, Malek;

doi: 10.1016/j.molcel.2016.11.024

pmid: 27912095

The RAS/MAPK Axis Gets Stressed Out

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Abstract

In this issue of Molecular Cell, Ritt et al. (2016) describe a stress-induced checkpoint that effectively suppresses RAS-MAPK signaling. This pathway, activated by agents such as Rigosertib that induce mitotic and oxidative stress, results in JNK-mediated inhibition of RAS-MAPK pathway components SOS and RAF.

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Genentech Inc.
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Keywords

Proto-Oncogene Proteins c-raf, ras Proteins, Signal Transduction

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