Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2016 English Publisher:Elsevier BVJournal:Molecular Cell, volume 62, pages 155-156 (issn: 1097-2765,

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Authors: Diana C, Cox; Thomas A, Cooper;

doi: 10.1016/j.molcel.2016.04.004

pmid: 27105111

Non-canonical RAN Translation of CGG Repeats Has Canonical Requirements

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Abstract

Repeat expansions cause dominantly inherited neurological disorders. In this issue of Molecular Cell, Kearse et al. (2016) examine the requirements for RAN translation of the CGG repeats that cause fragile X-associated tremor/ataxia syndrome, revealing similarities and differences with canonical translation.

Related Organizations

Baylor College of Medicine
United States

Keywords

Fragile X Messenger Ribonucleoprotein 1, Fragile X Syndrome, Tremor, Humans, Ataxia

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