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Let a Hundred Flowers Bloom: The Role of Context Dependence in Creating Phenotypic Diversity following Targeted Therapy

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2015 United States English Publisher:Elsevier BVJournal:Molecular Cell, volume 57, pages 763-764 (issn: 1097-2765, Copyright policy )
Authors: Lee, Michael J;

doi: 10.1016/j.molcel.2015.02.030

pmid: 25747655

handle: 20.500.14038/49941

Let a Hundred Flowers Bloom: The Role of Context Dependence in Creating Phenotypic Diversity following Targeted Therapy

Abstract

Using a newly developed computational platform, COSPER, Litvin et al. (2015) identify context-dependent interactions between MEK and interferon signaling that underlie sensitivity and resistance to MEK inhibition in melanoma.

Country
United States
Related Organizations
Keywords

Gene Expression Regulation, Neoplastic, MAP Kinase Signaling System, Systems Biology, Computational Biology, Humans, Interferon-alpha, Cell Biology, Interferon-beta, Molecular Biology, Cancer Biology

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 3
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
hybrid
Related to Research communities
Cancer Research