descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2013 English Publisher:Elsevier BVJournal:Molecular Cell, volume 51, pages 3-4 (issn: 1097-2765,

Authors: Caldas, Gina V.; DeLuca, Jennifer G.;

doi: 10.1016/j.molcel.2013.06.017

pmid: 23849628

Mad2 “Opens” Cdc20 for BubR1 Binding

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Abstract

In this issue of Molecular Cell, Han et al. (2013) demonstrate that Mad2 induces a conformational change in Cdc20 that permits BubR1 binding, thereby producing the physiologically relevant APC/C(Cdc20) inhibitor.

Related Organizations

Colorado State University
United States

Keywords

Cdc20 Proteins, Calcium-Binding Proteins, Cell Cycle Proteins, Cell Biology, Protein Serine-Threonine Kinases, Repressor Proteins, Mad2 Proteins, Humans, M Phase Cell Cycle Checkpoints, Molecular Biology

1 Research products, page 1 of 1

Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by a Mad2-Induced Functional Switch in Cdc20
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