Chromatin Insulators: Linking Genome Organization to Cellular Function
Copyright policy )Chromatin Insulators: Linking Genome Organization to Cellular Function
A growing body of evidence suggests that insulators have a primary role in orchestrating the topological arrangement of higher-order chromatin architecture. Insulator-mediated long-range interactions can influence the epigenetic status of the genome and, in certain contexts, may have important effects on gene expression. Here we discuss higher-order chromatin organization as a unifying mechanism for diverse insulator actions across the genome.
- Emory University United States
CCCTC-Binding Factor, Binding Sites, Genome, Models, Genetic, Cell Biology, Chromatin, Repressor Proteins, Gene Expression Regulation, Animals, Humans, Insulator Elements, Molecular Biology, Protein Binding
CCCTC-Binding Factor, Binding Sites, Genome, Models, Genetic, Cell Biology, Chromatin, Repressor Proteins, Gene Expression Regulation, Animals, Humans, Insulator Elements, Molecular Biology, Protein Binding
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