descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2011 English Publisher:Elsevier BVJournal:Molecular Cell, volume 42, pages 713-714 (issn: 1097-2765,

Authors: Macintyre, Andrew N.; Rathmell, Jeffrey C.;

doi: 10.1016/j.molcel.2011.06.003

pmid: 21700216

pmc: PMC3267323

PKM2 and the Tricky Balance of Growth and Energy in Cancer

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Abstract

In this issue of Molecular Cell, Lv et al. (2011) identify a novel feedback mechanism in which increased glycolysis induces the acetylation and chaperone-mediated autophagic degradation of the glycolytic regulator PKM2, revealing a novel metabolic feedback loop that drives tumor growth.

Related Organizations

Duke University
United States
Duke Medical Center
United States
Duke University Health System
United States
Duke University Hospital
United States

Keywords

Cell Biology, Molecular Biology

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