The BCL-2 Family Reunion
Copyright policy )The BCL-2 Family Reunion
B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.
- St. Jude Children's Research Hospital United States
Molecular Sequence Data, Apoptosis, Cell Biology, Endoplasmic Reticulum, Models, Biological, Permeability, Proto-Oncogene Proteins c-bcl-2, Multigene Family, Mitochondrial Membranes, Autophagy, Amino Acid Sequence, Molecular Biology, Sequence Alignment, Signal Transduction
Molecular Sequence Data, Apoptosis, Cell Biology, Endoplasmic Reticulum, Models, Biological, Permeability, Proto-Oncogene Proteins c-bcl-2, Multigene Family, Mitochondrial Membranes, Autophagy, Amino Acid Sequence, Molecular Biology, Sequence Alignment, Signal Transduction
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