An Orphan Nuclear Receptor Finds a Home

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2010 English Publisher:Elsevier BVJournal:Molecular Cell, volume 37, pages 155-157 (issn: 1097-2765,

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Authors: Kimmel, Alan R.;

doi: 10.1016/j.molcel.2010.01.008

pmid: 20122397

An Orphan Nuclear Receptor Finds a Home

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Abstract

In this issue of Molecular Cell, Lee et al. (2010) show that the retinoic acid receptor-related orphan receptor alpha (RORalpha) can suppress the Wnt/beta-catenin signaling pathway in a Wnt5a- and PKC-dependent manner that does not alter beta-catenin stabilization or the recruitment of beta-catenin to Wnt target promoters.

Related Organizations

National Institute of Diabetes and Digestive and Kidney Diseases
United States
National Institute of Health
Pakistan
National Institutes of Health
United States

Keywords

Wnt Proteins, Humans, Nuclear Receptor Subfamily 1, Group F, Member 1, Cell Biology, Receptor Tyrosine Kinase-like Orphan Receptors, Molecular Biology, Models, Biological, beta Catenin, Signal Transduction

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