Tat-SIRT1 Tango
Copyright policy )Tat-SIRT1 Tango
In a recent issue of Cell Host & Microbe, Kwon et al. (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation.
- University of California, San Francisco United States
Acquired Immunodeficiency Syndrome, Transcription, Genetic, T-Lymphocytes, NF-kappa B, Cell Biology, Lymphocyte Activation, Mice, Sirtuin 1, HIV-1, Animals, Humans, Sirtuins, tat Gene Products, Human Immunodeficiency Virus, Molecular Biology
Acquired Immunodeficiency Syndrome, Transcription, Genetic, T-Lymphocytes, NF-kappa B, Cell Biology, Lymphocyte Activation, Mice, Sirtuin 1, HIV-1, Animals, Humans, Sirtuins, tat Gene Products, Human Immunodeficiency Virus, Molecular Biology
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