YAP1 Meets Tumor Suppression
Copyright policy )YAP1 Meets Tumor Suppression
In this issue of Molecular Cell, Matallanas et al. (2007) demonstrate that RASSF1A-induced apoptosis impinges on the transcriptional coactivator YAP1, whose nuclear translocation and binding to p73 result in proper execution of the cell death pathway. Indeed, RASSF1A silencing in tumors inhibits YAP1-p73-dependent apoptosis.
Transcription, Genetic, Tumor Suppressor Proteins, Hippo Kinases, Nuclear Proteins, Apoptosis, Tumor Protein p73, YAP-Signaling Proteins, Cell Biology, Protein Serine-Threonine Kinases, Phosphoproteins, Serine-Threonine Kinase 3, DNA-Binding Proteins, Proto-Oncogene Proteins c-raf, Humans, Tumor Suppressor Protein p53, Molecular Biology, Adaptor Proteins, Signal Transducing, Protein Binding, Transcription Factors
Transcription, Genetic, Tumor Suppressor Proteins, Hippo Kinases, Nuclear Proteins, Apoptosis, Tumor Protein p73, YAP-Signaling Proteins, Cell Biology, Protein Serine-Threonine Kinases, Phosphoproteins, Serine-Threonine Kinase 3, DNA-Binding Proteins, Proto-Oncogene Proteins c-raf, Humans, Tumor Suppressor Protein p53, Molecular Biology, Adaptor Proteins, Signal Transducing, Protein Binding, Transcription Factors
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