New Wrinkles and Folds in Site-Specific Recombination

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2005 English Publisher:Elsevier BVJournal:Molecular Cell, volume 19, pages 433-435 (issn: 1097-2765,

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Authors: Segall, Anca M.; Craig, Nancy L.;

doi: 10.1016/j.molcel.2005.08.003

pmid: 16109368

New Wrinkles and Folds in Site-Specific Recombination

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Abstract

The new work of reveals a new site-specific recombination strategy to establish lysogeny, in which a double-stranded recombination substrate is assembled from the folded single-stranded DNA genome of the filamentous Vibrio cholerae phage CTXphi. This strategy allows the phage to use the host's recombinases while at the same time preventing inappropriate excision of the prophage.

Related Organizations

San Diego State University
United States
Johns Hopkins Medicine
United States
JOHNS HOPKINS UNIVERSITY
United States

Keywords

Recombinases, Recombination, Genetic, Integrases, Escherichia coli Proteins, Bacteriophages, Cell Biology, Molecular Biology, Vibrio cholerae

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