A RecA Filament Capping Mechanism for RecX Protein
Copyright policy )A RecA Filament Capping Mechanism for RecX Protein
The RecX protein is a potent inhibitor of RecA protein activities. RecX functions by specifically blocking the extension of RecA filaments. In vitro, this leads to a net disassembly of RecA protein from circular single-stranded DNA. Based on multiple observations, we propose that RecX has a RecA filament capping activity. This activity has predictable effects on the formation and disassembly of RecA filaments. In vivo, the RecX protein may limit the length of RecA filaments formed during recombinational DNA repair and other activities. RecX protein interacts directly with RecA protein, but appears to interact in a functionally significant manner only with RecA filaments bound to DNA.
- University of Wisconsin–Oshkosh United States
- University of Wisconsin–Madison United States
Adenosine Triphosphatases, DNA, Bacterial, Binding Sites, DNA Helicases, DNA, Single-Stranded, Cell Biology, DNA-Binding Proteins, Microscopy, Electron, Bacterial Proteins, Escherichia coli, Molecular Biology, Protein Binding
Adenosine Triphosphatases, DNA, Bacterial, Binding Sites, DNA Helicases, DNA, Single-Stranded, Cell Biology, DNA-Binding Proteins, Microscopy, Electron, Bacterial Proteins, Escherichia coli, Molecular Biology, Protein Binding
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