Microbiological production of omeprazole metabolites by Cunninghamella elegans

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2006 English Publisher:Elsevier BVJournal:Journal of Molecular Catalysis B: Enzymatic, volume 41, pages 87-91 (issn: 1381-1177,

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Authors: Clive M. Pearce; Marina V. Lushnikova;

doi: 10.1016/j.molcatb.2006.04.005

Microbiological production of omeprazole metabolites by Cunninghamella elegans

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Abstract

Incubation of Cunninghamella elegans ATCC 9245 and the anti ulcer drug omeprazole allowed putative fungal metabolites to be isolated in sufficient quantities for structural elucidation. Three metabolites produced by the fungi were isolated using semi-preparative HPLC and their structures identified by a combination of LC/MS(n) and NMR experiments. These isolates will be used as reference standards in the confirmatory analysis of mammalian metabolites of this drug.

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Fordham University
United States

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