Helicobacter pylori CagI is associated with the stability of CagA

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2016 English Publisher:Elsevier BVJournal:Microbial Pathogenesis, volume 99, pages 130-134 (issn: 0882-4010,

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Authors: Hua, Wang; Yizheng, Yao; Bin, Ni; Yixin, Shen; Xiaochun, Wang; Hongxing, Shen; Shihe, Shao;

doi: 10.1016/j.micpath.2016.07.017

pmid: 27544325

Helicobacter pylori CagI is associated with the stability of CagA

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Abstract

The type Ⅳ secretion system (T4SS) of H. pylori encoded by cag pathogenicity island mediates the injection of the toxin CagA, which is considered as a paradigm for bacterial carcinogenesis. T4SS is generally composed of a set of proteins, the majority of which still remain unclear. In this study, we have identified CagI, one of the T4SS proteins, which interacted with CagA and played an important role for CagA stability.

Related Organizations

Jiangsu University
China (People's Republic of)

Keywords

Type IV Secretion Systems, Antigens, Bacterial, Bacterial Proteins, Helicobacter pylori

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