Gingipain adhesin domains mediate Porphyromonas gingivalis adherence to epithelial cells

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2004 English Publisher:Elsevier BVJournal:Microbial Pathogenesis, volume 36, pages 205-209 (issn: 0882-4010,

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Authors: Tsute, Chen; Margaret J, Duncan;

doi: 10.1016/j.micpath.2003.12.001

pmid: 15001226

Gingipain adhesin domains mediate Porphyromonas gingivalis adherence to epithelial cells

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Abstract

Porphyromonas gingivalis, a Gram-negative oral anaerobe, interacts with epithelium lining the gingival sulcus. Continuing our studies on the role of gingipain cysteine proteinases in P. gingivalis adherence to epithelial cells, we showed that antibody raised to the recombinant adhesin domain of arg-gingipain A blocked bacterial attachment, providing new additional evidence that P. gingivalis adherence to epithelial cells is mediated by gingipain adhesin peptides.

Related Organizations

Forest Institute
United States

Keywords

Epithelial Cells, Antibodies, Bacterial, Bacterial Adhesion, Recombinant Proteins, Cell Line, Protein Structure, Tertiary, Cysteine Endopeptidases, Hemagglutinins, Genes, Bacterial, Gingipain Cysteine Endopeptidases, Humans, Cloning, Molecular, Adhesins, Bacterial, Porphyromonas gingivalis

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