Anthrax and the inflammasome
Copyright policy )Anthrax and the inflammasome
Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis). This review presents the current understanding of LT-induced activation of Nlrp1 in cells and its consequences for toxin-mediated effects in rodent toxin and spore challenge models.
- National Institutes of Health United States
- National Institute of Health Pakistan
- National Institute of Allergy and Infectious Diseases United States
Antigens, Bacterial, Cell Death, Inflammasomes, Macrophages, Bacterial Toxins, NLR Proteins, Dendritic Cells, Rats, Anthrax, Mice, Bacillus anthracis, Animals, Apoptosis Regulatory Proteins, Adaptor Proteins, Signal Transducing
Antigens, Bacterial, Cell Death, Inflammasomes, Macrophages, Bacterial Toxins, NLR Proteins, Dendritic Cells, Rats, Anthrax, Mice, Bacillus anthracis, Animals, Apoptosis Regulatory Proteins, Adaptor Proteins, Signal Transducing
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