Decoding Tat: the biology of HIV Tat posttranslational modifications

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2005 English Publisher:Elsevier BVJournal:Microbes and Infection, volume 7, pages 1,364-1,369 (issn: 1286-4579,

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Authors: Claudia, Hetzer; Wilma, Dormeyer; Martina, Schnölzer; Melanie, Ott;

doi: 10.1016/j.micinf.2005.06.003

pmid: 16046164

Decoding Tat: the biology of HIV Tat posttranslational modifications

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Abstract

The Tat protein is a viral transactivator that activates HIV transcription through complex interactions with RNA and host cell factors. Tat undergoes multiple posttranslational modifications that regulate the dynamics and complexity of these interactions. The biology of these modifications and their role in Tat function are reviewed.

Related Organizations

Helmholtz Association of German Research Centres
Germany
University of California, San Francisco
United States
German Cancer Research Center
Germany

Keywords

Gene Products, tat, HIV-1, Humans, tat Gene Products, Human Immunodeficiency Virus, Arginine, Protein Processing, Post-Translational

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