The oxadiazole antibacterials
Copyright policy )The oxadiazole antibacterials
The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). They show in vivo efficacy in murine models of peritonitis/sepsis and neutropenic thigh MRSA infection. They are bactericidal and orally bioavailable. The oxadiazoles show promise in treatment of MRSA infection.
- University of Notre Dame United States
Methicillin-Resistant Staphylococcus aureus, Mice, Inbred ICR, Oxadiazoles, Quantitative Structure-Activity Relationship, Microbial Sensitivity Tests, Peritonitis, Staphylococcal Infections, beta-Lactams, Anti-Bacterial Agents, Vancomycin-Resistant Enterococci, Mice, Animals, Female
Methicillin-Resistant Staphylococcus aureus, Mice, Inbred ICR, Oxadiazoles, Quantitative Structure-Activity Relationship, Microbial Sensitivity Tests, Peritonitis, Staphylococcal Infections, beta-Lactams, Anti-Bacterial Agents, Vancomycin-Resistant Enterococci, Mice, Animals, Female
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