Comparative mapping of host–pathogen protein–protein interactions
Copyright policy )Comparative mapping of host–pathogen protein–protein interactions
Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications. Here, we highlight the importance of harnessing genetic diversity of hosts and pathogens for uncovering the biochemical basis of pathogen restriction, virulence, fitness, and pathogenesis. We further suggest that integrating physical interaction data with orthogonal types of data will allow researchers to draw meaningful conclusions both for basic and translational science.
- University of California, San Francisco United States
- Gladstone Institutes United States
570, Bacterial Proteins (mesh), 610, Protein Interaction Mapping (mesh), 2.2 Factors relating to the physical environment (hrcs-rac), Microbiology, Viral Proteins, Bacterial Proteins, 0605 Microbiology (for), Protein Interaction Mapping, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Humans, Genetic Variation (mesh), Virulence (mesh), Humans (mesh), 31 Biological Sciences (for-2020), Virulence, 3107 Microbiology (for-2020), 1108 Medical Microbiology (for), Genetic Variation, 2.1 Biological and endogenous factors (hrcs-rac), Biological Sciences, Databases as Topic (mesh), Host-Pathogen Interactions (mesh), Infectious Diseases, Databases as Topic, Medical Microbiology, Infectious Diseases (rcdc), Microbiology (science-metrix), Host-Pathogen Interactions, Viral Proteins (mesh)
570, Bacterial Proteins (mesh), 610, Protein Interaction Mapping (mesh), 2.2 Factors relating to the physical environment (hrcs-rac), Microbiology, Viral Proteins, Bacterial Proteins, 0605 Microbiology (for), Protein Interaction Mapping, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Humans, Genetic Variation (mesh), Virulence (mesh), Humans (mesh), 31 Biological Sciences (for-2020), Virulence, 3107 Microbiology (for-2020), 1108 Medical Microbiology (for), Genetic Variation, 2.1 Biological and endogenous factors (hrcs-rac), Biological Sciences, Databases as Topic (mesh), Host-Pathogen Interactions (mesh), Infectious Diseases, Databases as Topic, Medical Microbiology, Infectious Diseases (rcdc), Microbiology (science-metrix), Host-Pathogen Interactions, Viral Proteins (mesh)
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