Cyclic di-GMP as a second messenger
Copyright policy )Cyclic di-GMP as a second messenger
In many bacteria bis-(3',5')-cyclic dimeric guanosine monophosphate (c-di-GMP) signaling determines the timing and amplitude of complex biological processes from biofilm formation and virulence to photosynthesis. Thereby, the tightly regulated temporal and spatial activity patterns of GGDEF and EAL domain proteins, which synthesize and degrade c-di-GMP, respectively, are currently being resolved. Although details of the mechanisms of c-di-GMP signaling are not yet determined, the recent presentation of PilZ as a candidate c-di-GMP binding-domain opens the field for experimental investigations. Besides its role as an intracellular signaling molecule in bacteria, c-di-GMP also acts as an intercellular signaling molecule between prokaryotes and also has effects in eukaryotes that could provide a perspective in cancer treatment.
- Achva Academic College Israel
- Hadassah Medical Center Israel
- Tel Hai Academic College Israel
- Karolinska Institute Sweden
Bacteria, Virulence, Intracellular Signaling Peptides and Proteins, Bacterial Physiological Phenomena, Second Messenger Systems, Proto-Oncogene Proteins p21(ras), Eukaryotic Cells, Bacterial Proteins, Biofilms, Cell Line, Tumor, Animals, Cyclic GMP, Locomotion, Cell Proliferation, Protein Binding
Bacteria, Virulence, Intracellular Signaling Peptides and Proteins, Bacterial Physiological Phenomena, Second Messenger Systems, Proto-Oncogene Proteins p21(ras), Eukaryotic Cells, Bacterial Proteins, Biofilms, Cell Line, Tumor, Animals, Cyclic GMP, Locomotion, Cell Proliferation, Protein Binding
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).304 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!