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Phosphodiesterases and preeclampsia

Name: Phosphodiesterases and preeclampsia
Keywords: Inflammation, Neovascularization, Pathologic, Phosphodiesterase Inhibitors, Phosphoric Diester Hydrolases, Hydrolysis, Vasodilator Agents, Thromboxanes, Arginine, Nitric Oxide, Epoprostenol

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2017 English Publisher:Elsevier BVJournal:Medical Hypotheses, volume 108, pages 94-100 (issn: 0306-9877,

Authors: Daniele Cristovao Escouto; Débora Montenegro Pasin; Claudia Capellari; Carlos Eduardo Poli-de-Figueiredo; Aline Parisotto; Anne Brandolt Larré; Bartira Ercília Pinheiro da Costa; +1 Authors

doi: 10.1016/j.mehy.2017.08.003

pmid: 29055408

Phosphodiesterases and preeclampsia

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Abstract

Antagonizing vasodilation has been considered one of the potential mechanisms underlying the pathophysiology of preeclampsia. Phosphodiesterases hydrolyze cGMP, interfering with the action of nitric oxide on vascular smooth muscle, thus causing vasoconstriction. We hypothesize that the phosphodiesterases in maternal plasma, phosphodiesterase-5 in particular, may be linked to clinical manifestations in preeclampsia syndrome.

Related Organizations

Pontifical Catholic University of Rio de Janeiro
Brazil

Keywords

Inflammation, Neovascularization, Pathologic, Phosphodiesterase Inhibitors, Phosphoric Diester Hydrolases, Hydrolysis, Vasodilator Agents, Thromboxanes, Arginine, Nitric Oxide, Epoprostenol, Muscle, Smooth, Vascular, Renin-Angiotensin System, Vasodilation, Pre-Eclampsia, Pregnancy, Cytokines, Humans, Female, Endothelium, Vascular, Signal Transduction

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