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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Medicina Clínicaarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Medicina Clínica
Article . 2009 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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Cardiotoxicidad tardía inducida por antraciclinas

Authors: Clara Pérez; Ma Antònia Agustí; Pilar Tornos;

Cardiotoxicidad tardía inducida por antraciclinas

Abstract

Las antraciclinas son antibioticos citotoxicos que se utilizan en el tratamiento de diferentes tipos de cancer. Se unen al acido desoxirribonucleico e interfieren en la sintesis de acidos nucleicos. Los farmacos mas utilizados de este grupo son la daunorrubicina (leucemias agudas y linfomas) y la doxorrubicina (leucemias agudas, linfomas y distintos tumores solidos). Otras antraciclinas comercializadas son epirrubicina e idarrubicina. La mitoxantrona no es una antraciclina, pero quimicamente es similar. La cardiotoxicidad es un efecto adverso caracteristico y grave de estos farmacos, aunque tambien pueden causar mielosupresion, mucositis, alopecia y lesiones graves de tejidos por extravasacion. La cardiotoxicidad, especialmente la que aparece a largo plazo, es un problema que ha ido adquiriendo importancia en los ultimos anos. Esto se debe fundamentalmente a un aumento de los casos detectados —secundario al incremento de la supervivencia de los pacientes tratados con antraciclinas en la infancia—, a la ausencia (hasta hace unos anos) de estrategias eficaces para su prevencion y a las graves consecuencias que conlleva para el paciente —una reduccion de la esperanza de vida—. Casi un 60% de los ninos diagnosticados de cancer reciben antraciclinas. El riesgo de

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Top 10%
Average
Related to Research communities
Cancer Research
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