Opioid Tolerance and Hyperalgesia

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2007 English Publisher:Elsevier BVJournal:Medical Clinics of North America, volume 91, pages 199-211 (issn: 0025-7125,

Copyright policy )

Authors: Grace, Chang; Lucy, Chen; Jianren, Mao;

doi: 10.1016/j.mcna.2006.10.003

pmid: 17321281

Opioid Tolerance and Hyperalgesia

- Summary
- Subjects
- Metrics

Abstract

Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed.

Related Organizations

Massachusetts General Hospital
United States
Harvard University
United States

Keywords

Analgesics, Opioid, Hyperalgesia, Risk Factors, Substance-Related Disorders, Chronic Disease, Humans, Nociceptors, Drug Tolerance

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	186
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%