Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2006 English Publisher:Elsevier BVJournal:Molecular and Cellular Endocrinology, volume 254-255, pages 91-96 (issn: 0303-7207,

Copyright policy )

Authors: M L, Gottsch; D K, Clifton; R A, Steiner;

doi: 10.1016/j.mce.2006.04.030

pmid: 16762492

Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis

- Summary
- Subjects
- Metrics

Abstract

Kisspeptins, which are products of the Kiss1 gene, and their receptor, GPR54, have emerged as key players in the regulation of gonadotropin-releasing hormone (GnRH) secretion. Mutations or targeted deletions of GPR54 produce isolated hypogonadotropic hypogonadism in humans and mice, indicating that signaling through this receptor is a prerequisite for sexual maturation. Centrally administered kisspeptins stimulate GnRH and gonadotropin secretion in prepubertal and adult animals. Kisspeptin-expressing neurons are direct targets for the negative and positive feedback actions of sex steroids, which differentially regulate the expression of KiSS-1 mRNA in various regions of the forebrain. This review highlights what is currently known about kisspeptin-GPR54 signaling in the regulation of the neuroendocrine reproductive axis.

Related Organizations

University of Washington
United States
University of Mary
United States

Keywords

Neurons, Kisspeptins, Reproduction, Tumor Suppressor Proteins, Puberty, Models, Biological, Neurosecretory Systems, Receptors, G-Protein-Coupled, Gonadotropin-Releasing Hormone, Gene Expression Regulation, Animals, Humans, RNA, Messenger, Gonadal Steroid Hormones, Receptors, Kisspeptin-1, Signal Transduction

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	115
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%