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Mathematical Biosciences
Article . 2007 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
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zbMATH Open
Article . 2007
Data sources: zbMATH Open
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Stochastic model for analysis of longitudinal data on aging and mortality

Authors: Yashin, Anatoli I.; Arbeev, Konstantin G.; Akushevich, Igor; Kulminski, Aliaksandr; Akushevich, Lucy; Ukraintseva, Svetlana V.;

Stochastic model for analysis of longitudinal data on aging and mortality

Abstract

Aging-related changes in a human organism follow dynamic regularities, which contribute to the observed age patterns of incidence and mortality curves. An organism's 'optimal' (normal) physiological state changes with age, affecting the values of risks of disease and death. The resistance to stresses, as well as adaptive capacity, declines with age. An exposure to improper environment results in persisting deviation of individuals' physiological (and biological) indices from their normal state (due to allostatic adaptation), which, in turn, increases chances of disease and death. Despite numerous studies investigating these effects, there is no conceptual framework, which would allow for putting all these findings together, and analyze longitudinal data taking all these dynamic connections into account. In this paper we suggest such a framework, using a new version of stochastic process model of aging and mortality. Using this model, we elaborated a statistical method for analyses of longitudinal data on aging, health and longevity and tested it using different simulated data sets. The results show that the model may characterize complicated interplay among different components of aging-related changes in humans and that the model parameters are identifiable from the data.

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Keywords

Aging, Stochastic Processes, Models, Statistical, Physiology (general), Homeostenosis, Stresses resistance, Physiological, cellular and medical topics, Physiological norms, Applications of statistics to biology and medical sciences; meta analysis, Allostatic load, Data Interpretation, Statistical, Humans, Stochastic process model of aging and mortality, Longitudinal data analysis, Mortality, Mathematics, Signal detection and filtering (aspects of stochastic processes)

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    71
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
71
Top 10%
Top 10%
Top 10%
bronze