descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2020 English Publisher:Elsevier BVJournal:Molecular Aspects of Medicine, volume 71, page 100,826 (issn: 0098-2997,

Authors: J.V. Cabral-Costa; A.J. Kowaltowski;

doi: 10.1016/j.mam.2019.10.003

pmid: 31630771

Neurological disorders and mitochondria

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Abstract

The brain is highly dependent on mitochondrial energy metabolism. As a result, mitochondrial dysfunction is a central aspect of many adult-onset neurological diseases, including stroke, ALS, Alzheimer's, Huntington's, and Parkinson's diseases. We review here how different mitochondrial functions, including oxidative phosphorylation, mitochondrial dynamics, oxidant generation, cell death regulation, Ca2+ homeostasis, and proteostasis are involved in these disorders.

Related Organizations

Universidade de São Paulo
Brazil
UNIVERSIDADE DE SAO PAULO
Brazil

Keywords

Neurodegenerative Diseases, Mitochondrial Dynamics, Oxidative Phosphorylation, Mitochondria, Oxidative Stress, Proteostasis, Humans, Calcium Signaling, Energy Metabolism, Reactive Oxygen Species

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