SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine
Copyright policy )SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine
The exocytotic release of neurotransmitters requires active transport into synaptic vesicles and other types of secretory vesicles. Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine transporters VMAT1 and 2, respectively). To date, no specific diseases have been attributed to a mutation in an SLC18 family member; however, polymorphisms in SLC18A1 and SLC18A2 may confer risk for some neuropsychiatric disorders. Additional members of this family include SLC18A4, expressed in insects, and SLC18B1, the function of which is not known. SLC18 is part of the Drug:H(+) Antiporter-1 Family (DHA1, TCID 2.A.1.2) within the Major Facilitator Superfamily (MFS, TCID 2.A.1).
- University of California, Los Angeles United States
Models, Molecular, Protein Conformation, Vesicular Acetylcholine Transport Proteins, Biological Transport, Heterotrimeric GTP-Binding Proteins, Models, Biological, Mice, Gene Expression Regulation, Multigene Family, Vesicular Monoamine Transport Proteins, Mutation, Animals, Humans, Biogenic Monoamines, Drosophila, Nervous System Diseases, Phosphorylation, Caenorhabditis elegans, Phylogeny
Models, Molecular, Protein Conformation, Vesicular Acetylcholine Transport Proteins, Biological Transport, Heterotrimeric GTP-Binding Proteins, Models, Biological, Mice, Gene Expression Regulation, Multigene Family, Vesicular Monoamine Transport Proteins, Mutation, Animals, Humans, Biogenic Monoamines, Drosophila, Nervous System Diseases, Phosphorylation, Caenorhabditis elegans, Phylogeny
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