Aging epigenetics: Causes and consequences

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2013 English Publisher:Elsevier BVJournal:Molecular Aspects of Medicine, volume 34, pages 765-781 (issn: 0098-2997,

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Authors: Covadonga, Huidobro; Agustin F, Fernandez; Mario F, Fraga;

doi: 10.1016/j.mam.2012.06.006

pmid: 22771540

Aging epigenetics: Causes and consequences

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Abstract

Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on genetic and environmental factors and, when it takes place in adult stem cells, it could play an important role in aging, although the underlying molecular mechanisms are still largely unknown.

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Keywords

Epigenomics, Aging, DNA Methylation, Epigenesis, Genetic, Histones, Adult Stem Cells, MicroRNAs, Animals, Humans, Gene-Environment Interaction, RNA Interference, Protein Processing, Post-Translational

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