descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2012 English Publisher:Elsevier BVJournal:Molecular Aspects of Medicine, volume 33, pages 605-611 (issn: 0098-2997,

Authors: Tonghui Ma; Hongwen Gao; Xuedong Fang; Hong Yang;

doi: 10.1016/j.mam.2012.03.002

pmid: 22476045

Water channel proteins in the peripheral nervous system in health and disease

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Abstract

The expression and function of aquaporins (AQPs) in the peripheral nervous system is a relatively under-investigated subject. Since the original description of AQP1 mRNA expression in the trigeminal ganglion in 2004, there has been significant progress in describing the expression, regulation and function of AQPs in the peripheral nervous system. Three out of the 13 mammalian AQPs (AQP1, AQP2 and AQP4) have been localized to neurons or glial cells in trigeminal ganglia, periodontal Ruffini endings, dorsal root ganglia and the enteric nervous system. Functional studies using knockout mice have suggested the involvement of AQP1 in peripheral pain perception. This review discusses current progress in this field and the possible involvement of AQPs in peripheral neuropathies.

Related Organizations

Jilin University
China (People's Republic of)
Jilin University
China (People's Republic of)
Liaoning Normal University
China (People's Republic of)

Keywords

Mice, Knockout, Neurons, Gene Expression, Peripheral Nervous System Diseases, Pain Perception, Aquaporins, Synaptic Transmission, Enteric Nervous System, Mice, Trigeminal Ganglion, Ganglia, Spinal, Animals, Humans, Mechanoreceptors

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