Receptors of anthrax toxin and cell entry
Copyright policy )Receptors of anthrax toxin and cell entry
Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation. The roles played by cellular factors in regulating the endocytosis of toxin-receptor complexes is also discussed.
- École Polytechnique Fédérale de Lausanne EPFL Switzerland
- Salk Institute for Biological Studies United States
Models, Molecular, Antigens, Bacterial, Receptors, Peptide, Protein Conformation, Bacterial Toxins, GTPase-Activating Proteins, Endosomes, Hydrogen-Ion Concentration, Endocytosis, Protein Subunits, Receptors, LDL, Bacillus anthracis, Low Density Lipoprotein Receptor-Related Protein-6, Animals, Humans, Adaptor Proteins, Signal Transducing
Models, Molecular, Antigens, Bacterial, Receptors, Peptide, Protein Conformation, Bacterial Toxins, GTPase-Activating Proteins, Endosomes, Hydrogen-Ion Concentration, Endocytosis, Protein Subunits, Receptors, LDL, Bacillus anthracis, Low Density Lipoprotein Receptor-Related Protein-6, Animals, Humans, Adaptor Proteins, Signal Transducing
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