Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2011 English Publisher:Elsevier BVJournal:Leukemia Research, volume 35, pages 689-692 (issn: 0145-2126,

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Authors: Carolin J, Teman; Sheryl R, Tripp; Sherrie L, Perkins; Eric J, Duncavage;

doi: 10.1016/j.leukres.2011.01.032

pmid: 21414663

Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

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Abstract

Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation.

Related Organizations

University of Utah
United States
ARUP Institute for Clinical and Experimental Pathology
United States
ARUP Laboratories (United States)
United States

Keywords

Adult, Aged, 80 and over, Male, Polyomavirus Infections, Middle Aged, Immunohistochemistry, Leukemia, Lymphocytic, Chronic, B-Cell, Polymerase Chain Reaction, Cohort Studies, DNA, Viral, Humans, Female, Polyomavirus, Aged

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