MATERIALS AND METHODS We reviewed the records of 303 patients who underwent transcatheter aortic valve replacement with the SAPIEN/SAPIEN XT valve (Edwards Lifesciences Corporation, Irvine, Calif) from November 2008 through August 2013. From this population, a study group was created of the 99 patients (32.9%) who underwent preopertive contrast-enhanced multidetector computed tomography with calculation of the Agatston aortic valve calcium score and aortic valve area. Categoric data are presented as counts with frequencies, and continuous data are presented as medians with interquartile ranges (IRQs). Transcatheter aortic valve oversize data are reported as percentages and were determined by the following formula: [(transcatheter aortic valve area/contrast-enhanced multidetector computed tomographically derived aortic valve area) 1]3 100. Logistic regression of dichotomous variables was done using the upper interquartile range Agatston score and lower interquartile range valve oversize calculation. Analysis was completed using JMP 10.0 software package (SAS Institute Inc, Cary, NC).