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Saudi Pharmaceutical Journal
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Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2017 English Publisher:Springer Science and Business Media LLCJournal:Saudi Pharmaceutical Journal, volume 25, pages 275-279 (issn: 1319-0164, Copyright policy )
Authors: Sapavat Madhavi; Reddymasu Sreenivasulu; Jyothsna Pragathi Yazala; Rudraraju Ramesh Raju;

doi: 10.1016/j.jsps.2016.06.005

pmid: 28344479

pmc: PMC5355550

Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents

Abstract

A series of ten novel chalcone incorporated quinazoline derivatives (11a-11j) were designed and synthesized. All the synthesized compounds were evaluated for their anticancer activities against four human cancer cell lines (A549, HT-29, MCF-7 and A375). Among them, four compounds, 11f, 11g, 11i and 11j showed more potent anticancer activity than the control drug, Combretastatin - A4.

Related Organizations
Keywords

Pharmacology, Cytotoxicity, Pharmaceutical Science, Gefitinib, RM1-950, Chalcones, Erlotinib, Resveratrol, Quinazolines, Original Article, Therapeutics. Pharmacology

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 87
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
87
Top 1%
Top 10%
Top 1%
Green
gold
Related to Research communities
Cancer Research