Sevoflurane-induced pica in female rats
Copyright policy )Sevoflurane-induced pica in female rats
We examined the effects of volatile anesthetics on pica, which can be used to assess nausea and vomiting in rats. We found that inhalation anesthesia with sevoflurane significantly induced pica in female but not male rats. Among the female rats, young rats (8 weeks old) were more susceptible to its induction than adult rats (20 weeks old) with ovariectomy or sham-surgery. Anti-emetic drugs that are used to prevent postoperative nausea and vomiting (PONV) inhibited the pica. These results suggest that sevoflurane-induced pica in young female rats has the potential to be an animal model of PONV in humans.
- Kaizuka City Hospital Japan
- Osaka University Japan
Postoperative nausea and vomiting, Male, Methyl Ethers, RM1-950, Eating, Sevoflurane, Anti-emetic drugs, Anesthetics, Inhalation, Postoperative Nausea and Vomiting, Pica, Animals, Antiemetics, Female, Therapeutics. Pharmacology, Rats, Wistar, Kaolin
Postoperative nausea and vomiting, Male, Methyl Ethers, RM1-950, Eating, Sevoflurane, Anti-emetic drugs, Anesthetics, Inhalation, Postoperative Nausea and Vomiting, Pica, Animals, Antiemetics, Female, Therapeutics. Pharmacology, Rats, Wistar, Kaolin
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).8 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!