Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity
Copyright policy )Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity
To investigate whether the development of tolerance to cow's milk (CM) by aged 4 years can be predicted with a skin prick test (SPT) and measurements of total or specific immunoglobulin E (IgE) in the serum, taken at the time of diagnosis of cow's milk hypersensitivity (CMH).Infants with immediate (n=95) or delayed (n=67) challenge reactions to CM were prospectively followed to aged 4 years. CMH status was assessed annually by CM challenges.By aged 2, 3, and 4 years, children with delayed reactions developed tolerance to CM faster than those with immediate reactions: 64%, 92%, and 96% versus 31%, 53%, and 63%, respectively. A wheal size of or=5 mm in SPT correctly identified 71% of 39 infants with persistent CMH. Milk-specific IgE or=2 kU/L correctly identified 71% of infants with persistent CMH.SPT and milk-specific IgE in the serum are useful prognostic indicators of the development of tolerance to CM in infants with CMH.
- Turku University Hospital Finland
- University of Helsinki Finland
Hypersensitivity, Immediate, Male, Infant, Immunoglobulin E, Milk Proteins, Prognosis, Infant Formula, ROC Curve, Predictive Value of Tests, Child, Preschool, Immune Tolerance, Soybean Proteins, Animals, Humans, Cattle, Female, Hypersensitivity, Delayed, Prospective Studies, Milk Hypersensitivity, Skin Tests
Hypersensitivity, Immediate, Male, Infant, Immunoglobulin E, Milk Proteins, Prognosis, Infant Formula, ROC Curve, Predictive Value of Tests, Child, Preschool, Immune Tolerance, Soybean Proteins, Animals, Humans, Cattle, Female, Hypersensitivity, Delayed, Prospective Studies, Milk Hypersensitivity, Skin Tests
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