A stability-indicating HPLC assay method for docetaxel
Copyright policy )A stability-indicating HPLC assay method for docetaxel
A novel stability-indicating high-performance liquid chromatographic assay method was developed and validated for docetaxel in the presence of degradation products generated from forced decomposition studies. A gradient HPLC method was developed to separate the drug from the degradation products, using a Hichrom RPB HPLC column. Mixture of water and acetonitrile was used as mobile phase. The flow rate was 1.0 ml/min and the detection was done at 230 nm. Using the above method one can carry out the quantitative estimation of impurity namely DCT-1 and docetaxel. The developed gradient LC method was subsequently validated.
Drug Stability, Reproducibility of Results, Technology, Pharmaceutical, Taxoids, Docetaxel, Antineoplastic Agents, Phytogenic, Chromatography, High Pressure Liquid
Drug Stability, Reproducibility of Results, Technology, Pharmaceutical, Taxoids, Docetaxel, Antineoplastic Agents, Phytogenic, Chromatography, High Pressure Liquid
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