Interferon-β antibodies have a higher affinity in patients with neutralizing antibodies compared to patients with non-neutralizing antibodies
Copyright policy )Interferon-β antibodies have a higher affinity in patients with neutralizing antibodies compared to patients with non-neutralizing antibodies
In this study, we investigated the affinity, determined by a relative affinity assay, using increasing concentrations of sodium-isothiocyanate to disrupt the antigen antibody binding of neutralizing and non-neutralizing antibodies against interferon-beta (IFNbeta)-1a and -1b in 73 serum samples of MS patients treated with IFNbeta-1a or -1b. Relative affinity values were significantly higher in NAB-positive compared to NAB-negative samples and in samples of IFNbeta-1a-treated patients compared to IFNbeta-1b. A significant positive correlation between relative affinity values and therapy duration indicates affinity maturation as another qualitative factor in IFNbeta neutralization.
- Innsbruck Medical University Austria
Analysis of Variance, Multiple Sclerosis, Time Factors, Enzyme-Linked Immunosorbent Assay, Interferon-beta, Cross Reactions, Binding, Competitive, Antibodies, Treatment Outcome, Neutralization Tests, Humans, Immunotherapy
Analysis of Variance, Multiple Sclerosis, Time Factors, Enzyme-Linked Immunosorbent Assay, Interferon-beta, Cross Reactions, Binding, Competitive, Antibodies, Treatment Outcome, Neutralization Tests, Humans, Immunotherapy
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