Infection of immunocompromised patients by avian H9N2 influenza A virus
Copyright policy )Infection of immunocompromised patients by avian H9N2 influenza A virus
Avian influenza A (H9N2) virus is transmitted sporadically from avian species to human causing mild diseases in immunocompetent person. We report two cases of human infection in immunocompromised patients in Hong Kong between 2008 and 2009. One patient had uneventful recovery with viral shedding at day 10 after symptom onset despite her underlying acute lymphoblastic leukaemia. The other patient with post-bone marrow transplant chronic graft-versus-host disease and bronhioltis obliterans went into respiratory failure. Genetic analysis revealed that these cases were caused by different genetic variants which are circulating in poultry in this region. Review of literature identified another 9 human cases reported in Southern China since 1988. It is possible that human infection with H9N2 is more common than what has been recognized. Continuous surveillance of H9N2 influenza virus infection in human is warranted.
- Queen Mary University of London United Kingdom
- University of Hong Kong China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
- Queen Mary Hospital China (People's Republic of)
- Hospital Authority China (People's Republic of)
Respiratory Insufficiency - diagnosis - etiology, China, Time Factors, Bone marrow transplantation, Genotype, Avian influenza A H9N2, Immunocompromised Host, Influenza, Human, Influenza A Virus, Influenza A Virus, H9N2 Subtype, Humans, Bone Marrow Transplantation, Immunocompromised host, H9N2 Subtype - classification - genetics - isolation and purification, Infant, Middle Aged, Influenza, Virus Shedding, Influenza A Virus, H9N2 Subtype - classification - genetics - isolation and purification, Human - complications - diagnosis - pathology - virology, Hong Kong, RNA, Viral, Female, Influenza, Human - complications - diagnosis - pathology - virology, Bone Marrow Transplantation - adverse effects, Respiratory Insufficiency
Respiratory Insufficiency - diagnosis - etiology, China, Time Factors, Bone marrow transplantation, Genotype, Avian influenza A H9N2, Immunocompromised Host, Influenza, Human, Influenza A Virus, Influenza A Virus, H9N2 Subtype, Humans, Bone Marrow Transplantation, Immunocompromised host, H9N2 Subtype - classification - genetics - isolation and purification, Infant, Middle Aged, Influenza, Virus Shedding, Influenza A Virus, H9N2 Subtype - classification - genetics - isolation and purification, Human - complications - diagnosis - pathology - virology, Hong Kong, RNA, Viral, Female, Influenza, Human - complications - diagnosis - pathology - virology, Bone Marrow Transplantation - adverse effects, Respiratory Insufficiency
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).95 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!