HOPX: The Unusual Homeodomain-Containing Protein
Copyright policy )HOPX: The Unusual Homeodomain-Containing Protein
The homeodomain-only protein homeobox (HOPX) is the smallest known member of the homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely expressed in diverse tissues, where it is critically involved in the regulation of proliferation and differentiation. In human skin, HOPX controls epidermal formation through the regulation of late differentiation markers, and HOPX expression correlates with the level of differentiation in cutaneous pathologies. In mouse skin, Hopx was additionally identified as a lineage tracing marker of quiescent hair follicle stem cells. This review discusses current knowledge of HOPX structure and function in normal and pathological conditions.
- University Hospital of Lausanne Switzerland
Homeodomain Proteins, Skin Neoplasms, Genes, Homeobox, Cell Differentiation, DNA Methylation, Sensitivity and Specificity, Gene Expression Regulation, Neoplastic, Mice, Tumor Cells, Cultured, Animals, Humans, Cell Proliferation
Homeodomain Proteins, Skin Neoplasms, Genes, Homeobox, Cell Differentiation, DNA Methylation, Sensitivity and Specificity, Gene Expression Regulation, Neoplastic, Mice, Tumor Cells, Cultured, Animals, Humans, Cell Proliferation
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