Beat-to-beat determinants of the beat-to-beat temporal and spatial variability of repolarization
Copyright policy )Beat-to-beat determinants of the beat-to-beat temporal and spatial variability of repolarization
The goal of this study was to compare the time series predictors of beat-to-beat variability in repolarization in healthy individuals.Spatial QRS- and T-vector amplitudes, spatial QRS-T, RR' and TT' angles, RR' and QT intervals, and QRS- and T-loop roundness were measured on 453 consecutive sinus beats in 168 healthy subjects (mean age 39.8±15.6years; 50% men; 93% white). Panel time-series regression models were adjusted by age, sex, and race. Appropriate time series of ECG metrics served as predictors and outcomes.Increase in T-loop roundness index by 0.1 was associated with 1.1° (95%CI 0.9-2.2; P=0.048) increase in corresponding TT' angle. One unit increase in a respiration index was associated with 4ms (95%CI 0.6-7.0; P=0.021) increase in QT interval.Spatial TT' angle and beat-to-beat variability in T-loop roundness represent intrinsic measures of repolarization variability. QT interval variability characterizes the effect of respiration and heart rate variability.
- Johns Hopkins Hospital United States
- Johns Hopkins University United States
- Johns Hopkins Medicine United States
- Oregon Health & Science University United States
Adult, Male, Models, Cardiovascular, Vectorcardiography, Reproducibility of Results, Sensitivity and Specificity, Electrocardiography, Heart Conduction System, Heart Rate, Reference Values, Heart Rate Determination, Humans, Computer Simulation, Female, Diagnosis, Computer-Assisted, Algorithms
Adult, Male, Models, Cardiovascular, Vectorcardiography, Reproducibility of Results, Sensitivity and Specificity, Electrocardiography, Heart Conduction System, Heart Rate, Reference Values, Heart Rate Determination, Humans, Computer Simulation, Female, Diagnosis, Computer-Assisted, Algorithms
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