Deficiencies of physiologic calcification inhibitors and low-grade inflammation in arterial calcification: lessons for cartilage calcification
Copyright policy )Deficiencies of physiologic calcification inhibitors and low-grade inflammation in arterial calcification: lessons for cartilage calcification
Apart from clinical parallels, similarities in the pathogenesis of arterial and articular cartilage calcification have come to light in recent years. These include the roles of aging, of chronic low-grade inflammation and of genetic and acquired dysregulation of inorganic pyrophosphate (PP(i)) metabolism. This review focuses on recent developments in understanding the pathogenesis of artery calcification pertinent to interpretation of the mechanistic basis for articular cartilage calcification in aging and osteoarthritis.
- University of California, San Diego United States
- University Hospital Cologne Germany
- University Hospital Münster Germany
- University of California, San Diego United States
- Klinik und Poliklinik für Kinder- und Jugendmedizin Germany
Cartilage, Articular, Arteritis, Extracellular Matrix Proteins, Matrix Gla Protein, Phosphoric Diester Hydrolases, Calcium-Binding Proteins, Calcinosis, Chondrocalcinosis, Arteries, Humans, Vascular Diseases, Pyrophosphatases
Cartilage, Articular, Arteritis, Extracellular Matrix Proteins, Matrix Gla Protein, Phosphoric Diester Hydrolases, Calcium-Binding Proteins, Calcinosis, Chondrocalcinosis, Arteries, Humans, Vascular Diseases, Pyrophosphatases
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