Marble quarries exploited in antiquity of the Denizli and Karacasu Basins (Turkey) were characterized by their petrography, carbon and oxygen isotopes, and cathodoluminescence. This study is an useful contribution for provenance studies of archeological artifacts composed of unknown marble. Marble quarries fromthe Hierapolis, Laodikeia, and Aphrodisias territories were considered; they constitute a homogeneous group of marble extraction districts. Collectively, they were among the most important sites for marble exploitation throughout antiquity from southwestern Anatolia, where only Afyon and Ephesus, which have already been studied extensively, were more important. In spite of that, the exportation of these marbles in ancient times has not yet been demonstrated. This is partially because their identification has never been fully addressed scientifically. Petrography, isotopes, and cathodoluminescence techniques used together are effective in discriminating among the study marbles. This could facilitate the determination of the provenance of these marbles in localmonuments and artifacts. However, it could be difficult to determine the marble provenances in cases where a larger set of possible provenances should be taken into consideration.