CLINICAL VIGNETTE A 49-year-old woman with diabetes underwent a midline inguinal hernia repair. Shewas later admitted for awound infection with sinus tract drainage into her peritoneum requiring another abdominal surgery. She received a dose of cefazolin intraoperatively followed by ticarcillin/clavulanate and vancomycin. In addition, she was started on fluoxetine for depression and hydrocodone as needed for pain. Three days later, cultures obtained at the time of surgery revealed methicillin-resistant Staphylococcus aureus; the ticarcillin/clavulanate was discontinued, and she remained on vancomycin. On postoperative day 9, she received a dose of fluconazole for oral thrush, and 30minutes later, she noted diffuse itching.Within hours, she experienced a diffuse andpainful vesicular eruption. The allergy and immunology service was consulted for evaluation of fluconazole allergy. Physical examination was notable for scattered erythematous papules, a few targetoid lesions (see Fig E1 in this article’s Online Repository at www. jacionline.org), and tense blisters (see Fig E2 in this article’s Online Repository at www.jacionline.org) involving the arms, legs, palms, labia, and tongue with a few erosions on the gingiva. The full version of this article, including a review of relevant issues to be considered, can be found online at www. jacionlineorg. If you wish to receive CME or MOC credit for the article, please see the instructions above. INSTRUCTIONS Credit can now be obtained, free for a limited time, by reading the review articles in this issue. Please note the instructions listed below: 1. Review the target audience, learning objectives and author disclosures. 2. Complete the pre-test online at www.jacionline.org (click on the Online CME heading). 3. Follow the online instructions to read the full version of the article, including the clinical vignette and review components. 4. Complete the post-test. At this time, you will have earned 1.00 AMA PRA Category 1 CME Credit. 5. Approximately 4 weeks later you will receive an online assessment regarding your application of this article to your practice. Once you have completed this assessment, you will be eligible to receive 2 MOC Part II Self-Assessment credits from the American Board of Allergy and Immunology. Date of Original Release: November 2012. Credit may be obtained for these courses until October 31, 2014. Copyright Statement: Copyright ! 2012-2014. All rights reserved. Target Audience: Physicians and researchers within the field of allergic disease. Accreditation/Provider Statements and Credit Designation: The American Academy of Allergy, Asthma & Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The AAAAI designates these educational activities for a maximum of 1 AMA PRA Category 1 Credit". Physicians should only claim credit commensurate with the extent of their participation in the activity. List of Design CommitteeMembers:David A. Khan, MD (author), and James T. Li, MD, PhD (series editor) Activity Objectives 1. To be able to recognize the most common cutaneous drug reaction. 2. To be able to identify the clinical characteristics of acute generalized exanthematous pustulosis (AGEP). 3. To be able to list drugs commonly associated with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Recognition of Commercial Support: This CME activity has not received external commercial support. Disclosure of Significant Relationships with Relevant Commercial Companies/Organizations: D. A. Khan serves on speakers’ bureaus for Genentech, Merck, Baxter, and Viropharma; receives research support from the Vanberg Family Foundation and the National Institutes of Health; is the Allied Health Chair for the American College of Allergy, Asthma & Immunology; and is a member of the Joint Task Force on Practice Parameters for the Joint Council of Allergy, Asthma & Immunology. J. T. Li has consulted for Abbott.