INSTRUCTIONS Credit can now be obtained, free for a limited time, by reading the review articles in this issue. Please note the instructions listed below: 1. Review the target audience, learning objectives and author disclosures. 2. Complete the pre-test online at www.jacionline.org (click on the Online CME heading). 3. Follow the online instructions to read the full version of the article, including the clinical vignette and review components. 4. Complete the post-test. At this time, you will have earned 1.00 AMA PRA Category 1 CME Credit . 5. Approximately 4 weeks later you will receive an online assessment regarding your application of this article to your practice. Once you have completed this assessment, you will be eligible to receive 2MOCPart II SelfAssessment credits from the American Board of Allergy and Immunology. Date of Original Release: October 2012. Credit may be obtained for these courses until September 30, 2014. Copyright Statement: Copyright 2012-2014. All rights reserved. Target Audience: Physicians and researchers within the field of allergic disease. Accreditation/Provider Statements and Credit Designation: The American Academy of Allergy, Asthma & Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The AAAAI designates these educational activities for a maximum of 1 AMA PRA Category 1 Credit . Physicians should only claim credit commensurate with the extent of their participation in the activity. List of DesignCommitteeMembers:Martin Steinhoff,MD, PhD, Ferda Cevikbas, PhD, Iwei Yeh, MD, Kim Chong, MD, J€org Buddenkotte, PhD, and Akihiko Ikoma, MD, PhD (authors), and James T. Li, MD, PhD (series editor) Activity Objectives 1. To identify clinical features that can guide the clinician to the diagnosis of the primary cause of chronic pruritus. 2. To apply knowledge of the differential diagnoses of chronic pruritus to formulate a desired diagnostic strategy. 3. To use themost effectivemanagement for each type of chronic pruritus. Recognition of Commercial Support: This CME activity has not received external commercial support. Disclosure of Significant Relationships with Relevant Commercial Companies/Organizations: M. Steinhoff has received grants from the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases. The rest of the authors declare that they have no relevant conflicts of interest. J. T. Li has consulted for Abbott.